The FY16 Defense Appropriations Act provides $16 million (M) to the Department of Defense Parkinson’s Research Program (PRP), formerly the Neurotoxin Exposure Treatment Parkinson’s Research Program (NETPRP), to support research of exceptional scientific merit leading to an understanding of the cause, prevention, and treatment of the loss of dopaminergic neurons in the substantia nigra that result in Parkinson’s disease. Applications to the FY16 PRP are being solicited by the U.S. Army Medical Research Acquisition Activity (USAMRAA). The managing agent for the anticipated Program Announcements/Funding Opportunities is the Congressionally Directed Medical Research Programs (CDMRP).
FY16 PRP Program Announcements and General Application Instructions for the following award mechanisms are posted on the Grants.gov website.
IMPORTANT: The PRP seeks to focus applications and direct funding by providing Focus Areas to address the critical needs in Parkinson’s disease research. Applications must address at least one of the Focus Areas noted below:
· Studies of the neurovascular unit (including neurons, glia, the microvasculature, and the blood-brain barrier) in Parkinson’s disease and changes associated with its treatment. (For both award mechanisms.)
· Identification and evaluation of mechanisms in early Parkinson’s disease involving olfactory, microbiome, gastrointestinal, and/or autonomic nervous systems. (For both award mechanisms.)
· Mechanisms of neuroplasticity and compensation in Parkinson’s disease, such as influences of sleep, exercise, and diet. (For both award mechanisms.)
· Underlying factors influencing the progression in Parkinson’s disease in specific community-based populations (e.g., Veterans) to identify the heterogeneity of Parkinson’s disease. (For Impact Award applications only.)
http://cdmrp.army.mil/funding/prp.shtml
Focused Idea Award - Letter of Intent due November 9, 2016
Assistant Professor level or above (or equivalent)
· Supports conceptually innovative research that could lead to critical discoveries in Parkinson’s disease research and/or patient care.
· Strong, appropriately qualified PI and research team.
· Must address at least one of the FY16 PRP Focus Areas.
· The application must articulate how the proposed research impacts the Parkinson’s disease population.
· Preliminary data are not required.
· Submission of a Letter of Intent is required prior to full application submission.
· Clinical trials are not allowed.
· Maximum funding of $350,000 for direct costs (plus indirect costs)
· Maximum period of performance is 3 years.
Impact Award- Letter of Intent due November 9, 2016
Assistant Professor level or above (or equivalent)
· Preproposal is required; application submission is by invitation only.
· Supports high-impact, potentially high-risk, studies that address at least one of the FY16 PRP Focus Areas.
· Potential impact of research may be near-term or long-term, but it must be significant and go beyond an incremental advancement.
· Proposed projects may include basic, translational, or clinical research NOT including clinical trials.
· Preliminary data to support feasibility are required.
· Partnering PI option:
o Provides a higher level of funding to support synergistic partnerships between two or three independent investigators collaborating on a single application.
PIs are expected to demonstrate within the application the synergistic components that will significantly advance the project such that the research outcomes could not otherwise be accomplished through independent efforts of a single PI.
Individual PIs:
· Maximum funding of $3 million (M) for total costs (includes direct and indirect)
· Maximum period of performance is 4 years
Partnering PI Option:
· Maximum funding of $5M for total costs (includes direct and indirect costs)
· Maximum period of performance is 4 years
A pre-application is required and must be submitted through the electronic Biomedical Research Application Portal (eBRAP) at https://eBRAP.org prior to the pre-application deadline. All applications must conform to the final Program Announcements and General Application Instructions that will be available for electronic downloading from the Grants.gov website. The application package containing the required forms for each award mechanism will also be found on Grants.gov. A listing of all CDMRP funding opportunities can be obtained on the Grants.gov website by performing a basic search using CFDA Number 12.420.
Applications must be submitted through the federal government’s single-entry portal, Grants.gov. For email notification when Program Announcements are released go to the CDMRP website (http://cdmrp.army.mil) and select Subscribe to Funding Opportunities & Program Communications. For more information about the PRP or other CDMRP-administered programs, please visit the CDMRP website (http://cdmrp.army.mil).
Point of Contact:
CDMRP Help Desk
301-682-5507
help@eBrap.org